MTOR and autosomal dominant polycystic kidney disease: However, renal cells in ADPKD present with increased rates of proliferation and mitogenic signaling through the receptor tyrosine kinases (RTKs) and downstream, potentially oncogenic effectors, such as BRAF, extracellular signal-regulated kinase (ERK), Src and mammalian target of rapamycin (mTOR) [19].