Activating receptors, including, but not limited to, killer cell lectin-like receptor K1 (KLRK1—best known as NKG2D), DNAX accessory molecule-1 (CD226—best known as DNAM-1) and the natural cytotoxicity receptors NKp46, NKp44, and NKp30, recognize stress-inducible ligands on tumor cells that are scarcely expressed in their normal counterparts [2,3,4,5]. Here, CD226 is linked to neoplasm.