CASP3 and B-cell chronic lymphocytic leukemia: The study conducted on the pro-apoptotic effects of acacetin in chronic lymphocytic leukemia (CLL) B-lymphocytes xenografts and healthy B-lymphocytes proved direct targeting of mitochondrial pathway via increased release of cytochrome c, caspase -3 activation, increased concentration of reactive oxygen species (ROS); and MMP collapse [165].