CASP3 and hepatocellular carcinoma: In A2780 cells wogonin inhibited proliferation and metastasis via reduction of VEGF, Bcl-2 and Akt expression, and augmentation of Bax expression and p53 caspase-3 cleavage [179] Cytotoxic effects of wogonin were observed in HCC cell lines and xenografts via inactivation of AKT signaling, leading to the elevated levels of H2O2 and ER release of Ca2+ [180].