The potency of genistein against HT-29 colon cancer showed that apoptosis was induced by increased caspase-3 activity at the transcriptional, protein, and enzymatic levels and reduced matrix metalloproteinase-2 (MMP2) activity [217] while it acted by inducing the mitochondrial pathway of apoptosis in HCT-116 and LoVo cells by inhibiting phosphorylation of Akt [218]. Here, CASP3 is linked to malignant colon neoplasm.