Furthermore, in B CLL, delphinidin-3-O-glucoside and delphinidin-3-O-rutinoside demonstrated pro-apoptotic effects through a redox-sensitive caspase -3 activation mechanism as well as dysregulation of the Bad/Bcl-2 pathway, by rapidly dephosphorylating Akt and Bad and downregulating Bcl-2 [204]. This evidence concerns the gene CASP3 and B-cell chronic lymphocytic leukemia.