To further explore the potential therapeutic benefit of autophagy induction in this α2(I) G610C OI mouse model, we treated mice with rapamycin, a well‐characterized autophagy stimulator.11, 12 Rapamycin is a commonly used immunosuppressant and chemotherapeutic drug which inhibits mTOR, a key nutrient sensitive serine‐threonine kinase. The gene discussed is MTOR; the disease is osteogenesis imperfecta.