However, there is no clear clinical phenotype associated with specific TACI mutations, suggesting that additional environmental or genetic factors contribute to TACI deficiency‐associated CVID.7, 8 BCR and TLR stimulation also induce NF‐κB activation and dysfunctional NF‐κB signaling is associated with various defects in B cell function,9 which potentially manifests as CVID.10, 11, 12, 13. This evidence concerns the gene TNFRSF13B and common variable immunodeficiency.