Moreover, as the NF‐κB1 and NF‐κB2 proteins were linked to the CVID phenotype in patients,10, 11, 12, 13 this emphasizes the possibility that defects in various components of the NF‐κB pathway could contribute to pathogenesis of immunodeficiencies in humans. The gene discussed is NFKB1; the disease is Immunodeficiency.