Moreover, as the NF‐κB1 and NF‐κB2 proteins were linked to the CVID phenotype in patients,10, 11, 12, 13 this emphasizes the possibility that defects in various components of the NF‐κB pathway could contribute to pathogenesis of immunodeficiencies in humans. This evidence concerns the gene NFKB2 and Immunodeficiency.