CELF4 and schizophrenia: Notably, ZNF804A was found to interact with splicing factors including RBFOX1/2 and mRNA-binding proteins such as CELF3/4.56 RBFOX1 has recently been implicated in schizophrenia in the largest published GWAS of the disorder7 and moreover, the targets of both RBFOX proteins and CELF4 are enriched for rare disruptive exonic mutations in people with schizophrenia.42 Given the number of RNA-binding proteins that interact with ZNF804A, we propose that ZNF804A is involved mRNA metabolism and alternative splicing.