At the time of its initial discovery as being associated with schizophrenia, the function of ZNF804A was unknown.20 Sequence analysis showed that ZNF804A and its 2 paralogs in the human genome, ZNF804B and GPATCH8 (see later), contain a single C2H2-type zinc finger domain that in other proteins has been shown to bind directly to DNA, RNA, protein, and lipids.21,22 Several studies have addressed the biological role of ZNF804A. This evidence concerns the gene GPATCH8 and schizophrenia.