ZNF804A and schizophrenia: At the time of its initial discovery as being associated with schizophrenia, the function of ZNF804A was unknown.20 Sequence analysis showed that ZNF804A and its 2 paralogs in the human genome, ZNF804B and GPATCH8 (see later), contain a single C2H2-type zinc finger domain that in other proteins has been shown to bind directly to DNA, RNA, protein, and lipids.21,22 Several studies have addressed the biological role of ZNF804A.