Conversely, the majority of studies [52–54] indicate that rs2293275 polymorphism in exon 10 of the LHCGR gene variant is strongly linked with PCOS (Table 4), while there are only a few reports that rs2293275 polymorphism is not associated with PCOS [39]. The gene discussed is LHCGR; the disease is polycystic ovary syndrome.