The major prognostic factors in HIV-cryptococcal meningitis patients for long-term mortality were altered neurological status, low CD4 cell count, high CSF fungal/Cryptococcal antigen burden, older age at diagnosis and possibly immune reconstitution.[58] Lower CD4 counts <50 cells/mm3 in Uganda are associated with slightly higher mortality.[59] Despite the improvements in care, mortality is unchanged hence the need for new prognostic markers to identify those at risk and the causes of mortality. Here, CD4 is linked to Cryptococcal meningitis.