A neutrophil response was associated with worse outcomes compared to eosinophil response in mice cryptococcal pulmonary infections.[47] Neutrophils activation as evidenced by high neutrophil CD64 levels has been found to play a role in systemic inflammation in HIV infected patients initiating ART[48] and may play a role in IRIS as they have been found to be activated in TB-IRIS. This evidence concerns the gene FCGR1A and tuberculosis.