Some of these studies have reported correlations of both GAA1 and GAA2 with the presence of a cardiomyopathy [1,3,23] and some with the extent of wall thickening [3,28], but it has not generally been investigated whether GAA2 is a predictor of cardiac structure change or dysfunction in FRDA independent of GAA1. The gene discussed is GPAA1; the disease is cardiomyopathy.