During ZIKV infection in this individual, there was similar strong induction of type I ISGs, exemplified by MX1, OAS3, RSAD2, and IFI27 genes (Cluster 2), but minimal coincident induction of chemokines involved in leukocyte chemotaxis (Cluster 1) (Fig 2B). This evidence concerns the gene IFI27 and Zika virus infectious disease.