Genes associated with cell differentiation and proliferation, such as BUB1, DLGAP5, PBK and CEP55 (Cluster 3) were upregulated during DENV infection but not ZIKV, while EGR1, HBEGF and MAFB (Cluster 4), were up-regulated at d17 POS during ZIKV infection (Fig 2B). The gene discussed is HBEGF; the disease is Zika virus infectious disease.