Furthermore, most of the pro-inflammatory genes found on this array, which we have previously identified to be increased with 22L infection (such as Cxcl10, Ccl8, Tnf, IL1a, and IL1b) [6,21,38,50], were similarly increased in the absence of TLR2 or C5aR1 signaling during scrapie infection. The gene discussed is C5AR1; the disease is infection.