We previously demonstrated that the Mcl‐1 small molecule inhibitor A‐1210477 was able to synergize with ABT‐199 to induce apoptosis in AML cell lines and primary patient samples by disrupting the Bim‐Mcl‐1 interaction.23 However, the drug combination also synergized to reduce proliferation of normal peripheral blood mononuclear cells (PMNCs), albeit at higher concentrations. The gene discussed is BCL2L11; the disease is acute myeloid leukemia.