RIPK1 and alcoholic liver cirrhosis: As shown in Figure 2, very strong RIPK3 staining but not RIPK1 was found in the necrotic area, indicating that RIPK3, but not RIPK1, was involved in alcoholic liver cirrhosis, consistent with previous studies showing RIPK3 is mediated in the mouse model of ethanol-induced liver injury and progression of ALD patients [27].