Circulating miR-20a could enhance tumor cell proliferation, migration, and invasion by targeting various pathways; for example, Du and his colleagues revealed that upregulated circulating miR-20a might suppress inhibitor β of nuclear factor- (NF-) κ B and therefore enhance activity of NF-κ B pathway and downstream molecules such as livin and survivin [47]. This evidence concerns the gene BIRC5 and neoplasm.