A third model, the lipoprotein(a) [Lp(a)] transgenic mouse [4], exhibits a milder hypercholesterolemia driven by expression of human apolipoprotein B which elevates LDL levels and the presence of Lp(a) in the circulation due to expression of human apolipoprotein(a) [apo(a)]. This evidence concerns the gene LPA and familial hypercholesterolemia.