APOC3 and atherosclerosis: Interestingly, a proteomic analysis of the livers of transgenic Apoc3 mice which display a hypertriglyceridaemic phenotype, but no atherosclerosis [32], also showed an upregulation of cytosolic antioxidant enzymes, albeit amongst a slightly different set of proteins to the Lp(a) mice, indicating that different lipoprotein profiles may elicit different responses with respect to the proteins that are regulated.