For example, the CCO method has been used to determine the risk of death associated with use of selective cyclooxygenase-2 inhibitors and nonselective nonsteroidal anti-inflammatory drugs after acute myocardial infarction [77] and the SCCS has been used to investigate the association between bupropion for smoking cessation and death [78]. The gene discussed is PTGS2; the disease is acute myocardial infarction.