CD8A and neoplasm: Different studies in patients undergoing surgery for breast, lung, and other cancers have shown that the combination of epidural with general anesthesia results in a significant increase of CD8-positive lymphocytes within the tumor microenvironment but a decrease in FOXP3-positive T cell infiltration [24, 30, 31], a preservation of NK cells and of the preoperative balance of the patient’s immune system and tumor microenvironment [32].