In contrast, especially in older female patients with high and persistent MOG titers, different multiphasic subtypes have been identified, including multiphasic disseminated encephalomyelitis (MDEM); ADEM followed by relapsing episodes of ON (ADEM-ON); NMOSD; and relapsing, steroid-responsive ON [9, 12, 20–27]. The gene discussed is MOG; the disease is acute disseminated encephalomyelitis.