A pill containing 35 μg EE and 0.18-0.25 μg NGM induced a nonsignificant decrease in PAI-1 levels, from 81.2 ng/ml to 76.5 ng/ml (ES = -4.7; p = 0.520), after three months of use by PCOS patients [33]. Here, SERPINE1 is linked to polycystic ovary syndrome.