CASP3 and breast adenocarcinoma: In another study, it was shown that the extract of B. laciniosa (a species of Bryonia genus) triggers the induction of apoptosis through increasing the activity of caspase-3 and caspase-8 in MCF-7 (human breast adenocarcinoma) and SiHa (human squamous cell carcinoma; cervix) cell lines24.