As a tissue specific biological process, the involvement of this GO term in various tumor associated genes, such a cadherin family, p38, and MYC, has been confirmed [84,85] In cancers, particularly renal carcinoma, genes that contribute to GO:0090095 have been reported to be up-regulated compared with other irrelevant genes [86], thereby conforming to the expression profile clustering function of such a GO term. This evidence concerns the gene MYC and neoplasm.