Senzer et al. (2013) incorporated a plasmid encoding for wild-type p53 (wt-p53) in a N-[1-(2,3Dioleoxloxypropyl]-N–N,Ntrimethylammonium (DOTAP): 1,2Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) liposomal nanoparticle, conjugated to an anti-transferrin antibody, enabling tumour specific targeting. Here, TF is linked to neoplasm.