Another study, focusing on treatment switches in BRAF-mutant melanoma patients is the currently recruiting SECOMBIT study: arm A on encorafenib and binimetinib until progression and then switching to ipilimumab and nivolumab; arm B on ipilimumab and nivolumab until progression and then switching to encorafenib and binimetinib; and arm C on encorafenib and binimetinib for 8 weeks and then switching to ipilimumab and nivolumab until progression and then encorafenib and binimetinib upon progression. This evidence concerns the gene BRAF and melanoma.