Moreover, specific modifications in LPS alter the immunological response to this glycolipid, which often plays an important role in infection; in addition to modulating the inflammatory response mediated by the MD2/TLR4 complex, specific modifications to LPS can alter bacterial susceptibility to immune offences such as cationic antimicrobial peptides and the complement system [5, 8, 16, 19, 137–148]. Here, TLR4 is linked to infection.