They suggested that IGF-1 may play a role in the pathogenesis of AIS; (as insufficient IGF-1 levels play a role in vascular diseases such as atherosclerosis and restenosis, atherosclerotic plaque involves many factors and IGF-1 have a vital role in its formation evident by presence of its receptors on smooth muscle cells, inflammatory cells, and arterial endothelial cells of atherosclerotic plaques) so, should be considered as a routine risk factor for stroke in the Chinese population. This evidence concerns the gene IGF1 and atherosclerosis.