AURKC and spermatogenic failure 5: Until now, only five mutations of AURKC have been described to be associated with macrozoospermia: c.144delC (p.L499Wfs22), c.744C>G (p.Y248*), c686G>A (p.C229Y), c.930+38G>A (occurs in the 3′-UTR), and c.436-2A>G (splicing site mutation that leads to the skipping of exons 5) [6–13].