In the last decade, five mutations (c.144delC (p.L49Wfs22), c.744C>G (p.Y248*), c686G>A (p.C229Y), c.930+38G>A (occurs in the 3′-UTR), and c.436-2A>G (splicing site mutation that leads to the skipping of exons 5)) [8–13] in the AURKC gene have been reported to be associated with macrozoospermia. Here, AURKC is linked to spermatogenic failure 5.