Notably, we found that 66.2% of tumour samples with p63 up-regulation also exhibited high levels of IRS1 expression A similar correlation was observed in samples with p63 down-regulation, in which 58% of the patients concomitantly displayed low levels of IRS1 transcripts (Fig. 4F, p-value= 4.293e-07). This evidence concerns the gene IRS1 and neoplasm.