Patients with ND1 mtDNA ≥ 3200 copies/μl plasma had a sixfold higher odds of 28-day mortality following adjustment for APACHE II and sepsis compared with patients with ND1 mtDNA < 3200 copies/μl plasma (OR, 6.4; 95% CI, 1.8–22.9; p = 0.004), similar to what was reported in the parent ND1 mtDNA study [5]. Here, MT-ND1 is linked to Sepsis.