When comparing patients with a history of calcinosis to those without, statistical significance between groups was maintained on univariate analysis for all treatments, except anti-IL1 agents as follows: Rituximab (OR 6.345, 95% CI 2.825–14.245), IVIG (OR 2.353 95% CI 1.479–3.743), anti-TNF-alpha (OR 3.797, 95% CI 1.812–7.960) and abatacept (OR 13.317, 95% CI 1.194–148.514). The gene discussed is TNF; the disease is calcinosis.