BRCA1 and breast carcinoma: Medimegh et al. [62] suggested that in the absence of deleterious mutations on BRCA1, wild type alleles of BRCA1 genetic variants seem to decrease the expression level of the BRCA1 in 50% of familial breast cancer cases through their interaction with micro-RNAs (miRNAs) that are increasingly recognized as mediators in a variety of biological processes including breast cancer [62].