MLH1 and endometrial carcinoma: By overexpressing or downregulating MLH1 in Ishikawa or RL95–2 cells, respectively, we observed that MLH1 overexpression reduced cell proliferation properties (Fig. 2) and increased cell apoptosis (Fig. 3) in response to cisplatin, indicating that MLH1 plays an important role in the cisplatin sensitivity of human endometrial carcinoma cells.