It is reported that HGF has pleiotropic functions, including proliferation, angiogenesis, anti-apoptosis, anti-autophagy, anti-inflammation and anti-fibrosis in the vascular ECs, myocardial cells, and other types of cells [7], however, the precise role of HGF- Met signaling in the etiology of CTEPH remains unknown. This evidence concerns the gene HGF and chronic thromboembolic pulmonary hypertension.