Activated HSCs can secrete hepatocyte growth factor (HGF), osteopontin (OPN), and laminin-5 and promote HCC metastasis [16, 18, 19]; they can also lead to drug resistance by producing HGF and laminin-332 [20, 21] and inhibiting the activation of p53 [22]. The gene discussed is SPP1; the disease is hepatocellular carcinoma.