Endaya et al. found that HCC-bearing mice with high activation of EpCAM signaling (characterized by EpCAM cleavage followed by the intracellular domain of EpCAM (EpICD) entering into the cell nucleus and transcription of downstream target genes-c-Myc) can recruit more human bone marrow-derived MSCs [137]. This evidence concerns the gene MYC and hepatocellular carcinoma.