The results showed that BMSC/IFN-β significantly attenuated HCC HepG2 and Huh7 cell proliferation in vitro by decreasing the proportion of S-phase cells, thus delaying hepatoma formation and inhibiting tumor growth in NOD/SCID mouse models by inhibiting the AKT/FOXO3a pathway [171]. This evidence concerns the gene IFNB1 and neoplasm.