Furthermore, in the multivariate analysis, age (HR = 1.587, 95% CI 1.130–2.230, P = 0.008), bile duct invasion (HR 1.657, 95% CI 1.211–2.269, P = 0.002), lymph node metastasis (HR 2.360, 95% CI 1.665–3.344, P < 0.001), and FGFR1 expression (HR 0.677, 95% CI 0.471–0.972, P = 0.035) were predicted as significant prognostic biomarkers for overall survival in pancreatic cancer. This evidence concerns the gene FGFR1 and metastatic malignant neoplasm in the lymph nodes.