FGFR1 and metastatic malignant neoplasm in the lymph nodes: However, in univariate analysis, overall survival was significantly associated with age (HR 1.451, 95% CI 1.073–1.961, P = 0.016), bile duct invasion (HR 1.469, 95% CI 1.099–1.963, P = 0.009), lymphovascular invasion (HR 1.455, 95% CI 1.088–1.944, P = 0.011), lymph node metastasis (HR 2.495, 95% CI 1.811–3.436, P < 0.001), and FGFR1 expression (HR 0.590, 95% CI 0.415–0.839, P = 0.003) (Table 3).