The clinical significance of FGFR1 overexpression has not been thoroughly investigated in pancreatic cancer for two reasons: (1) KRAS mutation, which does not have any targeted solution, is almost universal in pancreatic cancer; (2) FGFR1 overexpression is not exclusive with KRAS mutation [17, 20]. This evidence concerns the gene FGFR1 and familial pancreatic carcinoma.