The tendency of an increase the leptin/ghrelin ratio was noted in normal body weight men after the HC- compared to the HF-meal, especially 120 min after meal intake, while in the overweight/obese group, the mean values decreased postprandially, and increased after the HF-meal intake, but the differences were not significant, maybe due to too high standard error, or too small a study sample. This evidence concerns the gene GHRL and hydrops fetalis.