There is increasing evidence that cell surface adhesion proteins and ECM components are critical for tumor metastasis.[42,43] KAI1/CD82 is cell membrane protein that bind to ECM or adhesion protein.[24,44] Moreover, KAI1/CD82 can prevent angiogenesis by inhibiting the epithelial-mesenchymal transition (EMT), and further inhibit tumor invasion and metastasis.[25]. This evidence concerns the gene CD82 and neoplasm.