DLL4 is one of the ligands that regulate the activities of Notch pathways.[11,12] It is involved in the regulation of the formation and development of lymphatic vessels and blood vessels during embryonic development.[31] DLL4 expression highly correlates with malignant tumor angiogenesis and metastasis.[32] In this study, DLL4 expression was positively related to tumor grade, tumor size, LNM, DM, and TNM stage. This evidence concerns the gene DLL4 and cancer.