Since liver was the metabolism site for heavy metals, such as zinc and copper, which were highly affined to MTs.[55] Besides that, MTs was reported to have a relationship with the resistance to chemotherapy,[56] which meant the expression of MTs would decrease the effect of chemotherapy and lead to a worse prognostic in gastric and ovary cancers.[44,57]. The gene discussed is TIMM8A; the disease is ovarian cancer.