2012; Ding et al. 2013). To assess whether Q‐PAC treatment results in apoptosis, we monitored caspase 3/7 activity in treated GBM cells and healthy astrocytes. Q‐PAC dose dependently increased caspase 3/7 activity in U87 (F(6,11) = 24.30, p < 0.0001; Fig. 4a), RN1 (F(5,22) = 6.2, p = 0.001; Fig. 4b), SJH1 (F(6,7) = 4.83, p = 0.028; Figure S7d) and JK2 (F(5,6) = 5.7, p = 0.027; Figure S7e) cultures, consistent with an increase in apoptosis in these cell types, without affecting caspase 3/7 activity in healthy astrocytes (F(5,12) = 2.67, p = 0.08; Fig. 4c). This evidence concerns the gene CASP3 and glioblastoma.