Macrolides such as azithromycin or clarithromycin modulate CD4+ T cells by inhibiting mTOR,28 and the inhibitory effect of clarithromycin is restricted to Th2 responses.29 Statin is used in dyslipidemia to inhibit 3‐hydroxy‐3‐methylglutaryl (HMG)‐CoA reductase, which is the rate‐limiting enzyme of cholesterol biosynthesis. This evidence concerns the gene CD4 and metabolic syndrome.