Besides, it was reported that high level of CD40 expression on MDSCs correlated with upregulation of CXCR5 and promoted the recruitment of MDSCs to the cancer site.34 A recent study demonstrated that decreased CD40 expression on MDSCs correlated significantly with MDSC accumulation in gastric tumor‐bearing mice and CD40 activation using anti‐CD40 agonistic Abs induced the apoptosis of MDSCs.35 Therefore, further studies are required to elucidate the effect of downregulation of CD40 on MDSCs after oxaliplatin treatment. Here, CD40 is linked to cancer.