NR3C2 and neoplasm: Generally, cytotoxic drugs, such as gemcitabine and 5‐FU, have been found to selectively eliminate MDSCs, and combined with other immunotherapy, they improve the therapeutic effect.16, 41, 42 It has been reported that docetaxel induced selective depletion of the mannose receptor (MR)+ MDSCs, resulting in M1‐like MDSCs accumulation in tumor‐bearing mice.44 In addition to reduction of MDSCs, some agents modulate the suppressive function of MDSCs.