Receptor internalization has already been recognized as a means to inactivate the excited receptors, but in a recent research, it is considered not only to terminal their activation, but also to serve as a signal regulating the downstream effector.31 According to the literature, DR4 internalization can shift the sensitivity of cancer cells to TRAIL from one death receptor to another in certain circumstances.19 But whether the internalized TRAIL/DR4 complex can still induces or enhances apoptosis of aHSCs remains unclear and deserves more attention.32 The gene discussed is TNFSF10; the disease is cancer.