Deactivation and elimination of fibrogenic HSCs are an antifibrotic strategy, regardless of the cause of hepatic fibrosis.1, 33 It is reported that IFN‐γ is able to induce rapid killing of HSCs,14, 34 and INF‐α are capable of both decreasing HSC activation and stimulating its apoptosis.13, 35 In this study, we confirmed that pPB‐SSL can enhance apoptosis induction of TRAIL in aHSCs and inhibit fibrosis both in vitro and in vivo, and the apoptotic cell death is a direct reason for alleviated liver fibrosis. This evidence concerns the gene IFNG and Hepatic fibrosis.