The variant GG genotype in REV1 rs3087399 was associated with a decreased risk of rectal cancer in the codominant and recessive model (GG vs. AA; OR 0.13; 95% CI 0.02–0.96; p = 0.05; and GG vs. AA+AG; OR 0.12; 95% CI 0.02–0.90; p = 0.04). The gene discussed is REV1; the disease is rectal cancer.