EME1 and colorectal carcinoma: Czech cohort. The carriers of the TC genotype in EME1 rs12450550 had an associated increased CRC risk (TC vs. TT; odds ratio (OR) 1.19; 95% confidence interval (CI) 1.00–1.40; p = 0.05), with the same tendency observed for the presence of the variant C allele in the dominant model (TC+CC vs. TT; OR 1.19; 95% CI 1.02–1.40; p = 0.03).