However, CXCL4L1/PF-4var, later isolated from thrombin-stimulated platelets and differing from CXCL4/PF-4 in three carboxy-terminal amino acids, shows higher anti-angiogenic activity and stronger ability to inhibit tumor growth than CXCL4/PF-4 [52]. The gene discussed is PF4; the disease is neoplasm.