Indeed, CXCR4 is commonly expressed in a variety of solid and haematological malignancies including lung, colorectal, gastric, ovarian, prostate and pancreatic cancer, melanoma, esophageal, bladder, head and neck carcinoma, osteosarcoma, neuroblastoma, glioblastoma, and acute lymphoblastic leukaemia [2,20]. Here, CXCR4 is linked to melanoma.