In addition to its crucial involvement in MDSC recruitment, it has been reported that CXCL5 overexpression in non-small cell lung cancer (NSCLC) enhances both tumor growth and angiogenesis by a cyclooxygenase (COX-2) dependent mechanism, whereas its depletion attenuates this phenotype [173,174]. The gene discussed is CXCL5; the disease is non-small cell lung carcinoma.