First, the expression of CCR1 that binds to 6 ligands (CCL3, CCL4, CCL5, CCL7, CCL16, CCL23) has been shown to correlate with metastases in lung, prostate, cervical and hepatocellular carcinoma, multiple myeloma, T-cell leukaemia, and osteosarcoma [19,39]. Here, CCL5 is linked to osteosarcoma.