CXCR4 and melanoma: It has been reported that the overexpression of the chemokine receptor CXCR4 in melanoma cells is sufficient to promote metastatic accumulation of tumor cells in lungs, and pharmacological blocking of CXCR4 by a specific inhibitor prevents in vivo pulmonary metastases in CXCR4-B16 melanoma-bearing mice [220].