Notwithstanding, expression of CXCL2, CXCL3 and CXCL8 is increased in colon cancer compared with normal colon tissue and CXCL2 and CXCL3 expression has been found to be already upregulated in premalignant adenomas [34]. This evidence concerns the gene CXCL2 and malignant colon neoplasm.