Moreover, in major urinary protein (MUP)-urokinase-type plasminogen activator (uPA) transgenic mice, a model for ER and transient liver stress, blocking of TNFα and hepatic TNFR1 signaling prevents nonalcoholic steatohepatitis (NASH) in obese mice [53]. Here, PLAU is linked to metabolic dysfunction-associated steatohepatitis.