VEGFA and hereditary clear cell renal cell carcinoma: In renal cell carcinoma and hepatocellular carcinoma for example, only CD105+ and CD90+ cells respectively, release exosomes able to stimulate production and release of the Vascular Endothelial Growth Factor (VEGF); TIC derived exosomes, once engulfed in endothelial cells, activate the VEGF autocrine loop through the delivery of different ncRNAs [31,96].