TLR4 expressed by hepatocytes responds to LPS and regulates the expression of hepcidin, a key iron‐regulatory protein implicated in obesity and NAFLD, via the MyD88‐IRAK‐TRAF6‐JNK‐AP‐1 axis (Lu et al, 2016; Lee et al, 2017). Here, TLR4 is linked to metabolic dysfunction-associated steatotic liver disease.