While there is no standard of care for non-clear cell metastatic RCCs (referred to here as non–ccRCC), retrospective analyses indicate that VEGFR-targeted agents provide some efficacy in metastatic tRCC, with an objective response rate of 30% and a median progression-free survival (PFS) duration of 7.1–8.2 months [8, 9]. Here, KDR is linked to nonpapillary renal cell carcinoma.