Given that the DHX36- and DHX9-dependent transcripts included many genes with a known role in cancer pathways, such as MAPK3/ERK1 or FOXM1 [50, 51], we considered the mutational and expression profiles of DHX36 and DHX9 in cancers to evaluate a potential contribution of both helicases in the oncogenic process. The gene discussed is MAPK3; the disease is cancer.