Moreover, the results of KEGG analysis revealed that the host genes of significantly dysregulated circRNAs were involved in many important CRC-related pathways such as Deleted in Colorectal Carcinoma (DCC) mediated attractive signaling, Netrin-1 signaling, Loss of Function of SMAD2/3 in Cancer, SMAD2/3 MH2 Domain Mutants in Cancer, TGFBR1 LBD Mutants in Cancer, SMAD4 MH2 Domain Mutants in Cancer, and Loss of Function of SMAD4 in Cancer [30–33]. This evidence concerns the gene SMAD4 and cancer.