Several pathways resulted particularly dragged into cell aggressive phenotype such as Aryl Hydrocarbon Receptor Signaling; OX40 Signaling Pathway, Antigen Presentation Pathway, Estrogen-mediated S-phase Entry, Cell Cycle, G1/S Checkpoint Regulation, Vitamin D and seleno-proteins, known as potentially important in tumor development and progression. This evidence concerns the gene TNFRSF4 and neoplasm.