We found that our models performed well on a variety of ADRs in terms of AUC including (1) skin-related ADRs such as dermatitis perioral, skin striae and acneiform eruption, (2) metabolic-related ADRs including alkalosis hypokalaemic and increased insulin requirement, (3) muscle-related steroid myopathy and (4) eye related cataract subcapsular. This evidence concerns the gene INS and skin disorder.